A. Hi Ann,
When we are building custom frames, the interior is brushed out removing any loose dust and debris. The glass is cleaned using a non-ammonia based cleaner and the picture is fit.
If this is a very old frame, we may sometimes line the interior of the rabbet with a foil tape.
Any framed artwork should be opened and cleaned at least once every 10-15 years. Despite a dust cover on the backside, a ghosting layer of film will develop on the interior side of the glass over time.
Sincerely,